TY - JOUR
T1 - Microencapsulation based on emulsification for producing pharmaceutical products
T2 - A literature review
AU - Huang, Hua Jiang
AU - Chen, Xiao Dong
AU - Yuan, Wei Kang
PY - 2006
Y1 - 2006
N2 - In this paper, microencapsulation based on emulsification coupling with solvent evaporation, ionotropic gelation, coacervation technique, and spray drying are critically reviewed. The introduction of biocompatible polymers, especially polyelectrolytes, as wall-forming materials are included. Membrane emulsification, surface modification, preparation of multilayer microcapsules, characterization methods, as well as modeling of drug release are summarized. This review suggests that membrane emulsification coupled with the ionotropic gelation/complex coacervation is the most promising method for microencapsulation under the mild conditions. Multilayer microcapsules using layer-by-layer complex coacervation, are efficient in obtaining the desired properties.
AB - In this paper, microencapsulation based on emulsification coupling with solvent evaporation, ionotropic gelation, coacervation technique, and spray drying are critically reviewed. The introduction of biocompatible polymers, especially polyelectrolytes, as wall-forming materials are included. Membrane emulsification, surface modification, preparation of multilayer microcapsules, characterization methods, as well as modeling of drug release are summarized. This review suggests that membrane emulsification coupled with the ionotropic gelation/complex coacervation is the most promising method for microencapsulation under the mild conditions. Multilayer microcapsules using layer-by-layer complex coacervation, are efficient in obtaining the desired properties.
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U2 - 10.1002/apj.5500140318
DO - 10.1002/apj.5500140318
M3 - Article
AN - SCOPUS:33745804739
SN - 0969-1855
VL - 14
SP - 515
EP - 544
JO - Developments in Chemical Engineering and Mineral Processing
JF - Developments in Chemical Engineering and Mineral Processing
IS - 3-4
ER -