Microencapsulation based on emulsification for producing pharmaceutical products: A literature review

Hua Jiang Huang, Xiao Dong Chen, Wei Kang Yuan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In this paper, microencapsulation based on emulsification coupling with solvent evaporation, ionotropic gelation, coacervation technique, and spray drying are critically reviewed. The introduction of biocompatible polymers, especially polyelectrolytes, as wall-forming materials are included. Membrane emulsification, surface modification, preparation of multilayer microcapsules, characterization methods, as well as modeling of drug release are summarized. This review suggests that membrane emulsification coupled with the ionotropic gelation/complex coacervation is the most promising method for microencapsulation under the mild conditions. Multilayer microcapsules using layer-by-layer complex coacervation, are efficient in obtaining the desired properties.

Original languageEnglish (US)
Pages (from-to)515-544
Number of pages30
JournalDevelopments in Chemical Engineering and Mineral Processing
Volume14
Issue number3-4
StatePublished - Jul 14 2006

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