TY - JOUR
T1 - Microfluidic devices for the analysis of single cells
T2 - leaving no protein uncounted.
AU - Navratil, Marian
AU - Whiting, Christofer E.
AU - Arriaga, Edgar A.
PY - 2007/6/16
Y1 - 2007/6/16
N2 - Microfluidic devices are revolutionizing bioanalysis, and designs capable of detecting single protein molecules are now available. Two recently described microfluidic devices provide information on the number of beta(2)-adrenergic receptors in individual cultured insect cells and measure the degradation of phycobilisomes in individual cyanobacteria, respectively. This latter experiment, which included the analysis of three single cells in parallel, heralds a bright future for high-throughput single-cell analyzers. These devices could greatly advance research in signal transduction and studies of the effects of environmental stimuli or xenobiotics on cellular responses.
AB - Microfluidic devices are revolutionizing bioanalysis, and designs capable of detecting single protein molecules are now available. Two recently described microfluidic devices provide information on the number of beta(2)-adrenergic receptors in individual cultured insect cells and measure the degradation of phycobilisomes in individual cyanobacteria, respectively. This latter experiment, which included the analysis of three single cells in parallel, heralds a bright future for high-throughput single-cell analyzers. These devices could greatly advance research in signal transduction and studies of the effects of environmental stimuli or xenobiotics on cellular responses.
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U2 - 10.1126/stke.3882007pe29
DO - 10.1126/stke.3882007pe29
M3 - Article
C2 - 17536099
AN - SCOPUS:38449103674
SN - 1937-9145
VL - 2007
SP - pe29
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 388
ER -