Microfluidic models for natural killer/cancer cell interactions in metastasis

Heather E. Bomberger, Behiye Kodal, Martin Felices, David K. Wood

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Natural Killer (NK) cell-based immunotherapies are becoming increasingly popular for treating solid tumors due to their role in tumor surveillance. However, much is still unknown about NK/cancer cell interactions in metastasis, including which stage of metastasis NK cells most often target cancer cells. Additionally, fundamental differences between murine and human immune systems limit the value of murine model systems in studying NK cell-based immunotherapies, such as Trispecific Killer Engagers (TriKEs). Therefore, we developed microfluidic models of metastasis to study NK/cancer cells interactions and TriKEs as an immunotherapy.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1153-1154
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Bibliographical note

Funding Information:
This work is supported by the University of Minnesota National Cancer Institute Physical Sciences Oncology Center (U54 PS-OC). Portions of this work were conducted in the Minnesota Nano Center supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network under Award Number ECCS-1542202. I would like to acknowledge the Wood and Felices labs, Hansol Kim for assisting, and Dan McDonald.

Funding Information:
This work is supported by the University of Minnesota National Cancer Institute Physical Sciences Oncology Center(U54PS-OC).PortionsofthisworkwereconductedintheMinnesotaNanoCentersupportedbytheNational Science Foundation through the National Nano Coordinated Infrastructure Network under Award Number ECCS-1542202.IwouldliketoacknowledgetheWoodandFeliceslabs,HansolKimforassisting,andDanMcDonald.

Publisher Copyright:
© 2020 CBMS-0001

Keywords

  • Immunotherapy
  • Metastasis
  • Microfluidics
  • Natural Killer Cells

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