Microfluidic selection and applications of aptamers

Renee K. Mosing, Michael Bowser

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

The high affinity and specificity of aptamers make them ideal reagents for a wide range of analytical applications. It is not surprising that they are finding application in microfluidics as well. CE has proven to be an efficient technique for isolating aptamers. Aptamers have been used as affinity reagents in CE assays. Aptamer-based chromatography stationary phases have demonstrated unique selectivities. Possibly the application that holds the highest potential is aptamer microarrays for screening proteomic samples.

Original languageEnglish (US)
Pages (from-to)1420-1426
Number of pages7
JournalJournal of Separation Science
Volume30
Issue number10
DOIs
StatePublished - Jul 1 2007

Keywords

  • Aptamer
  • Capillary electrophoresis
  • Chromatography
  • Microarray
  • SELEX

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