MicroRNA as Biomarkers of Malignant Mesothelioma

C. D. Hoang, Robert A Kratzke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Malignant pleural mesothelioma is a disease with poor prognosis and no cure. Worldwide, the incidence of this cancer problem continues to rise. The biology and tumorigenesis of this complex mesenchymal-type tumor remains incompletely understood. Over the past decade, emerging evidence has demonstrated that microRNAs, small nonprotein coding single-strand RNA negatively regulating gene expression, are deranged and exert significant biologic effects in multiple malignancies. This review will provide an update of the current state of microRNA translational research aimed at unraveling the novel biomarkers pertinent in several clinical problems of mesothelioma.

Original languageEnglish (US)
Title of host publicationTranslating MicroRNAs to the Clinic
PublisherElsevier Inc.
Pages203-221
Number of pages19
ISBN (Print)9780128005538
DOIs
StatePublished - Jan 1 2017

Keywords

  • Asbestos
  • Biomarker
  • Biphasic
  • Epithelioid
  • Gene
  • Interactome
  • Mesothelioma
  • MicroRNA
  • Microarray
  • Sarcomatoid

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