Microsomal phospholipase A2 is activated by surfactant toxins in 3T3 mouse fibroblasts

Kawaguchi Hideaki, Thomas W. Shier

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4 Scopus citations


In 3T3 mouse fibroblasts that were treated by surfactant toxins such as staphylococcal delta toxin, melittin from bee venom and lysolecithin, microsomal phospholipase A2 (PLA2) was activated. However, these toxins did not activate PLA2 when added to cell-free homogenates or microsomal preparations. The maximal activation was achieved at 1 mM Ca2+ pH 8.5. The microsomal PLA2 stimulated by these toxins had a high fatty acid specificity (C-2 position) toward arachidonic acid.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalToxicology Letters
Issue number2-3
StatePublished - Feb 1987


  • Phospholipase A
  • Swiss mouse 3T3 fibroblast
  • lysolecithin
  • melittin
  • staphylococcal delta toxin


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