TY - GEN
T1 - Mimicking the nanostructure of bone using a polymer-induced liquid-precursor (PILP) mineralization process
AU - Jee, Sang Soo
AU - Li, Yuping
AU - Douglas, Elliot P.
AU - Gower, Laurie B.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - During bone formation, intrafibrillar mineralization leads to an interpenetrating nanostructured composite, in which crystals of hydroxyapatite (HA) are crystallographically aligned and embedded within the collagen fibrils. Our group has demonstrated that intrafibrillar mineralization can be achieved in vitro by using a Polymer-Induced- Liquid-Precursor (PILP) mineralization process, in which the fluidity of this amorphous mineral precursor allows it to be pulled into the interstices of collagen fibrils via capillary forces, and upon solidification and crystallization, produces an interpenetrating composite that reproduces the nanostructured architecture of bone. Here, we demonstrate the effects of collagen structure on the ability to mineralize synthetic collagen scaffolds.
AB - During bone formation, intrafibrillar mineralization leads to an interpenetrating nanostructured composite, in which crystals of hydroxyapatite (HA) are crystallographically aligned and embedded within the collagen fibrils. Our group has demonstrated that intrafibrillar mineralization can be achieved in vitro by using a Polymer-Induced- Liquid-Precursor (PILP) mineralization process, in which the fluidity of this amorphous mineral precursor allows it to be pulled into the interstices of collagen fibrils via capillary forces, and upon solidification and crystallization, produces an interpenetrating composite that reproduces the nanostructured architecture of bone. Here, we demonstrate the effects of collagen structure on the ability to mineralize synthetic collagen scaffolds.
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M3 - Conference contribution
AN - SCOPUS:84872131572
SN - 9788880800842
T3 - A Global Road Map for Ceramic Materials and Technologies: Forecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme
BT - A Global Road Map for Ceramic Materials and Technologies
T2 - 2nd International Congress on Ceramics, ICC 2008
Y2 - 29 June 2008 through 4 July 2008
ER -