Mimicking the nanostructure of bone using a polymer-induced liquid-precursor (PILP) mineralization process

Sang Soo Jee, Yuping Li, Elliot P. Douglas, Laurie B. Gower

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

During bone formation, intrafibrillar mineralization leads to an interpenetrating nanostructured composite, in which crystals of hydroxyapatite (HA) are crystallographically aligned and embedded within the collagen fibrils. Our group has demonstrated that intrafibrillar mineralization can be achieved in vitro by using a Polymer-Induced- Liquid-Precursor (PILP) mineralization process, in which the fluidity of this amorphous mineral precursor allows it to be pulled into the interstices of collagen fibrils via capillary forces, and upon solidification and crystallization, produces an interpenetrating composite that reproduces the nanostructured architecture of bone. Here, we demonstrate the effects of collagen structure on the ability to mineralize synthetic collagen scaffolds.

Original languageEnglish (US)
Title of host publicationA Global Road Map for Ceramic Materials and Technologies
Subtitle of host publicationForecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme
StatePublished - Dec 1 2008
Event2nd International Congress on Ceramics, ICC 2008 - Verona, Italy
Duration: Jun 29 2008Jul 4 2008

Publication series

NameA Global Road Map for Ceramic Materials and Technologies: Forecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme

Other

Other2nd International Congress on Ceramics, ICC 2008
CountryItaly
CityVerona
Period6/29/087/4/08

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