Minimally invasive microwave ablation provides excellent long-term outcomes for otherwise inaccessible hepatocellular cancer

Ariella M. Altman, Alexandria Coughlan, Dip M. Shukla, Robben Schat, Benjamin Spilseth, Schelomo Marmor, Jane Y.C. Hui, Todd M. Tuttle, Eric H. Jensen

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives: Thermal ablation can be used as a bridge to transplant or with curative intent for hepatocellular carcinoma (HCC). We report our experience with laparoscopic ablation of HCC in patients deemed inaccessible by the percutaneous approach. Methods: We performed a retrospective review of surgical ablations from 2009 to 2017. Patient demographics, disease and treatment characteristics, and outcomes were abstracted from the medical record. Kaplan-Meier modeling was performed for survival and recurrence. Results: Thirty-three patients were included with a median age of 62 (interquartile range [IQR], 57-67). Most patients were male (76%) and Caucasian (70%). Ninety-seven percent had underlying cirrhosis. Median model for end stage liver disease-sodium was 9.5 (IQR, 8-12). The median maximal diameter of ablated lesions was 2.6 cm (IQR, 1.8-3.0). Thirty-nine lesions were ablated; 97% were completed laparoscopically. The median maximal diameter of the ablation zone was 4.8 cm (IQR, 3.8-5.7) with a median difference of ablation zone to the tumor of 2.0 cm (IQR, 1.5-2.75). Twelve patients received additional treatment. Median disease-free survival was 66.7 months and median follow-up 42.9 months. Disease recurrence occurred in 13 patients (39%)—systemic recurrence in 6%, intrahepatic recurrence in 27% and local recurrence in 6%. Conclusion: Laparoscopic thermal ablation of HCC is safe and provides good oncologic outcomes for otherwise inaccessible tumors.

Original languageEnglish (US)
Pages (from-to)1218-1224
Number of pages7
JournalJournal of Surgical Oncology
Volume121
Issue number8
DOIs
StatePublished - Jun 1 2020

Bibliographical note

Funding Information:
The authors of this manuscript would like to acknowledge Stephanie Lundgren for her administrative support of this project and Hailey McCaul for her research assistance. Dr Altman is in part supported by the Institute of Basic and Applied Research in Surgery and the VFW Fund of the University of Minnesota.

Publisher Copyright:
© 2020 Wiley Periodicals, Inc.

Keywords

  • disease recurrence
  • hepatocellular carcinoma
  • laparoscopic surgery
  • minimally invasive surgery
  • thermal ablation

PubMed: MeSH publication types

  • Journal Article

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