Minimum Information about a Biosynthetic Gene cluster

Marnix H. Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B. Biggins, Kai Blin, Irene De Bruijn, Yit Heng Chooi, Jan Claesen, R. Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Düsterhus, Daniel J. Edwards, David P. Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule, Michalis HadjithomasAnthony S. Haines, Eric J N Helfrich, Matthew L. Hillwig, Keishi Ishida, Adam C. Jones, Carla S. Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Kötter, Daniel Krug, Joleen Masschelein, Alexey V. Melnik, Simone M. Mantovani, Emily A. Monroe, Marcus Moore, Nathan Moss, Hans Wilhelm Nützmann, Guohui Pan, Amrita Pati, Daniel Petras, F. Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J. Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K. Apel, Carl J. Balibar, Emily P. Balskus, Francisco Barona-Gómez, Andreas Bechthold, Helge B. Bode, Rainer Borriss, Sean F. Brady, Axel A. Brakhage, Patrick Caffrey, Yi Qiang Cheng, Jon Clardy, Russell J. Cox, René De Mot, Stefano Donadio, Mohamed S. Donia, Wilfred A. Van Der Donk, Pieter C. Dorrestein, Sean Doyle, Arnold J M Driessen, Monika Ehling-Schulz, Karl Dieter Entian, Michael A. Fischbach, Lena Gerwick, William H. Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Höfte, Susan E. Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L. Klassen, Nancy P. Keller, Jan Kormanec, Oscar P. Kuipers, Tomohisa Kuzuyama, Nikos C. Kyrpides, Hyung Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y. Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Méndez, Mikko Metsä-Ketelä, Jason Micklefield, Douglas A. Mitchell, Bradley S. Moore, Leonilde M. Moreira, Rolf Müller, Brett A. Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S. Osburne, Bohdan Ostash, Shelley M. Payne, Jean Luc Pernodet, Miroslav Petricek, Jörn Piel, Olivier Ploux, Jos M. Raaijmakers, José A. Salas, Esther K. Schmitt, Barry Scott, Ryan F. Seipke, Ben Shen, David H. Sherman, Kaarina Sivonen, Michael J. Smanski, Margherita Sosio, Evi Stegmann, Roderich D. Süssmuth, Kapil Tahlan, Christopher M. Thomas, Yi Tang, Andrew W. Truman, Muriel Viaud, Jonathan D. Walton, Christopher T. Walsh, Tilmann Weber, Gilles P. Van Wezel, Barrie Wilkinson, Joanne M. Willey, Wolfgang Wohlleben, Gerard D. Wright, Nadine Ziemert, Changsheng Zhang, Sergey B. Zotchev, Rainer Breitling, Eriko Takano, Frank Oliver Glöckner

Research output: Contribution to journalReview articlepeer-review

342 Scopus citations

Abstract

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

Original languageEnglish (US)
Pages (from-to)625-631
Number of pages7
JournalNature Chemical Biology
Volume11
Issue number9
DOIs
StatePublished - Aug 18 2015

Bibliographical note

Funding Information:
M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO; Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme (Joint Call OCEAN.2011–2: Marine microbial diversity— new insights into marine ecosystems functioning and its biotechnological potential) under the grant agreement no. 287589 (Micro B3). M.C. was supported by a Biotechnology and Biological Sciences Research Council (BBSRC) studentship (BB/J014478/1). The GSC is supported by funding from the Natural Environment Research Council (UK), the National Institute for Energy Ethics and Society (NIEeS; UK), the Gordon and Betty Moore Foundation, the National Science Foundation (NSF; US) and the US Department of Energy. The Manchester Synthetic Biology Research Centre, SYNBIOCHEM, is supported by BBSRC/ Engineering and Physical Sciences Research Council (EPSRC) grant BB/M017702/1. We thank P. d’Agostino, P.R. August, R. Chau, C.D. Deane, S. Diethelm, L. Fernandez-Martinez, A. El Gamal, C. Garcia De Gonzalo, T.H. Grossman, C.-J. Huang, S. Kodani, A.L. Leandrini, I.A. MacNeil, M. Metelev, E.M. Molly, C. Olano, M. Ortega, L. Ray, K. Reynolds, A. Ross, I.N. Silva, R. Teufel, G. Thibodeaux, J. Tietz and D. Widdick for their contributions in the community annotation. We thank R. Baltz, M. Bibb, C. Boddy, C. Corre, E. Dittmann, H. Gramajo, N. Ichikawa, H. Ikeda, P. Jensen, C. Khosla, R. Li, M. Marahiel, D. Mohanty, C. Moore, W. Nierman, D.-C. Oh, E. Schmidt, Y. Shen, D. Stevens, B. Tudzynski and S. Van Lanen for useful comments on an early draft version of the community standard. We are grateful to three anonymous referees for their constructive suggestions.

Fingerprint Dive into the research topics of 'Minimum Information about a Biosynthetic Gene cluster'. Together they form a unique fingerprint.

Cite this