Minnesota Center for Twin and Family Research

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Abstract

The Minnesota Center for Twin and Family Research (MCTFR) comprises multiple longitudinal, community-representative investigations of twin and adoptive families that focus on psychological adjustment, personality, cognitive ability and brain function, with a special emphasis on substance use and related psychopathology. The MCTFR includes the Minnesota Twin Registry (MTR), a cohort of twins who have completed assessments in middle and older adulthood; the Minnesota Twin Family Study (MTFS) of twins assessed from childhood and adolescence into middle adulthood; the Enrichment Study (ES) of twins oversampled for high risk for substance-use disorders assessed from childhood into young adulthood; the Adolescent Brain (AdBrain) study, a neuroimaging study of adolescent twins; and the Siblings Interaction and Behavior Study (SIBS), a study of adoptive and nonadoptive families assessed from adolescence into young adulthood. Here we provide a brief overview of key features of these established studies and describe new MCTFR investigations that follow up and expand upon existing studies or recruit and assess new samples, including the MTR Study of Relationships, Personality, and Health (MTR-RPH); the Colorado-Minnesota (COMN) Marijuana Study; the Adolescent Brain Cognitive Development (ABCD) study; the Colorado Online Twins (CoTwins) study and the Children of Twins (CoT) study.

Original languageEnglish (US)
Pages (from-to)746-752
Number of pages7
JournalTwin Research and Human Genetics
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2019

Bibliographical note

Funding Information:
Research reported in this article was supported by the National Institute of Aging of the National Institutes of Health under award numbers R01AG06886 (MTSADA; PI: M. M.) and R01AG053217 (MTR-RPH; PIs: R. F. K., G. I. R.); National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award numbers R37AA09367 (MTFS; PI: M. M.), R21AA017314 (AdBrain; PI: S. M. M.) and R01AA11886 (SIBS; PI: M. M.); National Institute on Drug Abuse of the National Institutes of Health under award numbers R37DA05147 (MTFS; PI: W. G. I.), R01DA042755 (COMN; PIs: J. K. H., C. H., M. M., S. V.), U01DA041120 (ABCD; PIs: M. M. L., W. G. I.), U01DA046413 (CoTwins; PIs: S. V., N. P. F.), R01DA037904 (PI: S. V.), R01DA044283 (PI: S. V.), U01DA024417 (PI: W. G. I.), R01DA024417 (PI: W. G. I.) and K01DA037280 (PI: S. W.); National Institute of Mental Health of the National Institutes of Health under award numbers R01MH37860 (MTR; PI: D. T. L.) and R01MH066140 (SIBS; PI: M. M.); and Grant Number 60780 from the John Templeton Foundation as part of their Genetics and Human Agency initiative (SIBS; PIs: J. J. L., M. M.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the John Templeton Foundation. The research was also supported by resources from the University of Minnesota’s Center for Magnetic Resonance Research (P41-RR008079, P41-EB015894, P30-NS076408), and the Minnesota Supercomputing Institute.

Keywords

  • Addiction
  • GWAS
  • adoption study
  • development
  • endophenotypes
  • longitudinal
  • molecular genetics
  • neurocognitive
  • neuroimaging
  • personality
  • psychopathology
  • psychophysiology
  • substance use
  • twin study

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