TY - JOUR
T1 - miRNA signature of schwannomas
T2 - Possible role(s) of "tumor: Suppressor" miRNAs in benign tumors
AU - Erkan, Erdogan Pekcan
AU - Breakefield, Xandra O.
AU - Saydam, Okay
PY - 2011
Y1 - 2011
N2 - miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miRNA expression profiling of human vestibular schwannomas using an array representing 407 known miRNAs in order to explore the role of miRNAs in the tumorigenesis of schwannomas. We found that miR-7 functions as a "tumor suppressor" by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1. Interestingly, in this study, we also observed that several previously described potential tumor suppressor miRNAs that are down-regulated in malignant tumors were up-regulated in schwannomas. Here we discuss the possibility that "tumor suppressor" miRNAs may play a role in the transition stage(s) of cancer from benign to malignant forms.
AB - miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miRNA expression profiling of human vestibular schwannomas using an array representing 407 known miRNAs in order to explore the role of miRNAs in the tumorigenesis of schwannomas. We found that miR-7 functions as a "tumor suppressor" by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1. Interestingly, in this study, we also observed that several previously described potential tumor suppressor miRNAs that are down-regulated in malignant tumors were up-regulated in schwannomas. Here we discuss the possibility that "tumor suppressor" miRNAs may play a role in the transition stage(s) of cancer from benign to malignant forms.
KW - Ack1
KW - Benign tumors
KW - Neurofibromatosis 2 (NF2)
KW - Schwannomas
KW - Tumor suppressor miRNAs
KW - miR-7
UR - http://www.scopus.com/inward/record.url?scp=80052043279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052043279&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.251
DO - 10.18632/oncotarget.251
M3 - Article
C2 - 21454924
AN - SCOPUS:80052043279
SN - 1949-2553
VL - 2
SP - 265
EP - 270
JO - Oncotarget
JF - Oncotarget
IS - 3
ER -