Mixed-model segregation analysis of schizophrenia in the lindelius Swedish pedigrees

George P. Vogler, Irving I. Gottesman, Matthew K. McGue, D. C. Rao

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families. Results of the best-fitting mixed-model solutions are consistent with multifactorial transmission and no major gene. However, numerical instabilities prevented formal hypothesis testing, so an irrefutable genetic mechanism remains unidentified. Alternative research strategies that exploit recent advances in molecular genetics are discussed.

Original languageEnglish (US)
Pages (from-to)461-472
Number of pages12
JournalBehavior genetics
Volume20
Issue number4
DOIs
StatePublished - Jul 1990

Keywords

  • mixed model
  • pedigrees
  • schizophrenia
  • segregation analysis

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