Abstract
Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.
Original language | English (US) |
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Pages (from-to) | 836-839 |
Number of pages | 4 |
Journal | Pediatric Blood and Cancer |
Volume | 58 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2012 |
Keywords
- Epidemiology
- Infants
- Leukemia
- MLL