MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study

Thien N. Sam, John H. Kersey, Amy M Linabery, Kimberly J. Johnson, Nyla A. Heerema, Joanne M. Hilden, Stella M. Davies, Gregory H. Reaman, Julie A Ross

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.

Original languageEnglish (US)
Pages (from-to)836-839
Number of pages4
JournalPediatric Blood and Cancer
Volume58
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Epidemiology
  • Infants
  • Leukemia
  • MLL

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