Abstract
Gene regulatory networks are useful models for biologists to understand the interactions among genes in living organisms. In this work, we consider a special class of gene regulatory networks, called logical networks, where the "links" among genes are inferred by logic analysis of phylogenetic profiles. We provide a formalization of logic networks, and introduce a membrane computing model for reconstructing logical networks and reproducing their dynamics. An example logical network is simulated by using software P-Lingua and MeCoSim. The simulation result shows that membrane computing is a versatile framework for modeling different biological scenarios.
Original language | English (US) |
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Pages (from-to) | 445-464 |
Number of pages | 20 |
Journal | International Journal of Unconventional Computing |
Volume | 9 |
Issue number | 5-6 SPEC. ISSUE |
State | Published - 2013 |
Keywords
- Gene
- Genetic network
- Logic network
- Membrane computing
- P system
- System biology