TY - JOUR
T1 - Modulation of erythrocyte-endothelial interactions and the vasocclusive severity of sickling disorders
AU - Hebbel, R. P.
AU - Moldow, C. F.
AU - Steinberg, M. H.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The abnormal adherence of sickle erythrocytes to cultured human vascular endothelium varies among patients and correlates with vasocclusive severity within and among the different sickling disorders. For individual patients, the development of an acute vasocclusive event is not accompanied by an increase in the inherent propensity for their erythrocytes to adhere to endothelium. However, the onset of vasocclusion appears to be associated with the appearance of plasma factors, such as fibrinogen, which enhance the adherence of sickle erythrocytes to endothelium. In addition, sickle erythrocytes adhere even more avidly to injured endothelium and under hyperosmolar conditions. Thus, the overall clinical severity of the sickling disorders appears to correlate with the inherent propensity for sickle erythrocytes to adhere to endothelium, and changes in the red cells' environment may help precipitate crises by the sudden facilitation of erythrocyte/endothelial interactions.
AB - The abnormal adherence of sickle erythrocytes to cultured human vascular endothelium varies among patients and correlates with vasocclusive severity within and among the different sickling disorders. For individual patients, the development of an acute vasocclusive event is not accompanied by an increase in the inherent propensity for their erythrocytes to adhere to endothelium. However, the onset of vasocclusion appears to be associated with the appearance of plasma factors, such as fibrinogen, which enhance the adherence of sickle erythrocytes to endothelium. In addition, sickle erythrocytes adhere even more avidly to injured endothelium and under hyperosmolar conditions. Thus, the overall clinical severity of the sickling disorders appears to correlate with the inherent propensity for sickle erythrocytes to adhere to endothelium, and changes in the red cells' environment may help precipitate crises by the sudden facilitation of erythrocyte/endothelial interactions.
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U2 - 10.1182/blood.v58.5.947.bloodjournal585947
DO - 10.1182/blood.v58.5.947.bloodjournal585947
M3 - Article
C2 - 7296004
AN - SCOPUS:0019808315
SN - 0006-4971
VL - 58
SP - 947
EP - 952
JO - Blood
JF - Blood
IS - 5
ER -