TY - JOUR
T1 - Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010
AU - Banerjee, Ritu
AU - Robicsek, Ari
AU - Kuskowski, Michael A.
AU - Porter, Stephen
AU - Johnston, Brian D
AU - Sokurenko, Evgeni
AU - Tchesnokova, Veronika
AU - Price, Lance B.
AU - Johnson, James R
PY - 2013/12
Y1 - 2013/12
N2 - We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.
AB - We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.
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U2 - 10.1128/AAC.01604-13
DO - 10.1128/AAC.01604-13
M3 - Article
C2 - 24080662
AN - SCOPUS:84887467705
SN - 0066-4804
VL - 57
SP - 6385
EP - 6388
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -