TY - JOUR
T1 - Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli
AU - Johnson, James R.
AU - Russo, Thomas A.
PY - 2005/10/5
Y1 - 2005/10/5
N2 - Molecular epidemiological analyses of extraintestinal pathogenic Escherichia coli (ExPEC), which are also called "uropathogenic E. coli" since they are the principle pathogens in urinary tract infection, involve structured observations of E. coli as they occur in the wild. Careful selection of subjects and use of appropriate methods for genotyping and statistical analysis are required for optimal results. Molecular epidemiological studies have helped to clarify the host-pathogen relationships, phylogenetic background, reservoirs, and transmission pathways of ExPEC, to assess potential vaccine candidates, and to delineate areas for further study. Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies.
AB - Molecular epidemiological analyses of extraintestinal pathogenic Escherichia coli (ExPEC), which are also called "uropathogenic E. coli" since they are the principle pathogens in urinary tract infection, involve structured observations of E. coli as they occur in the wild. Careful selection of subjects and use of appropriate methods for genotyping and statistical analysis are required for optimal results. Molecular epidemiological studies have helped to clarify the host-pathogen relationships, phylogenetic background, reservoirs, and transmission pathways of ExPEC, to assess potential vaccine candidates, and to delineate areas for further study. Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies.
KW - Antimicrobial resistance
KW - Escherichia coli
KW - Molecular epidemiology
KW - Pathogenicity
KW - Phylogenetics
KW - Urinary tract infection
KW - Virulence factors
UR - http://www.scopus.com/inward/record.url?scp=24144465937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24144465937&partnerID=8YFLogxK
U2 - 10.1016/j.ijmm.2005.07.005
DO - 10.1016/j.ijmm.2005.07.005
M3 - Review article
C2 - 16238015
AN - SCOPUS:24144465937
VL - 295
SP - 383
EP - 404
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
SN - 1438-4221
IS - 6-7
ER -