Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine

U. Sailaja; M. Shahin Thayyil; N. S. Krishna Kumar; G. Govindaraj; K. L. Ngai

doi:10.1016/j.ejps.2016.11.024

Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine

U. Sailaja, M. Shahin Thayyil, N. S. Krishna Kumar, G. Govindaraj, K. L. Ngai

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	European Journal of Pharmaceutical Sciences
Volume	99
DOIs	https://doi.org/10.1016/j.ejps.2016.11.024
State	Published - Mar 1 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

Broadband dielectric spectroscopy
Dielectric relaxation strength
Glass transition
Nizatidine
Perphenazine

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title = "Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine",

abstract = "The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.",

keywords = "Broadband dielectric spectroscopy, Dielectric relaxation strength, Glass transition, Nizatidine, Perphenazine",

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T1 - Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine

AU - Sailaja, U.

AU - Shahin Thayyil, M.

AU - Krishna Kumar, N. S.

AU - Govindaraj, G.

AU - Ngai, K. L.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.

AB - The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.

KW - Broadband dielectric spectroscopy

KW - Dielectric relaxation strength

KW - Glass transition

KW - Nizatidine

KW - Perphenazine

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JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

ER -

Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine

Abstract

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Keywords

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