Molecular modeling studies on 11β-aminoethoxyphenyl and 7α-aminoethoxyphenyl estradiols. evidence suggesting a common hydrophobic pocket in estrogen receptor

Jacques H. Poupaert; Didier M. Lambert; Joseph Vamecq; Yusuf J. Abul-Hajj

doi:10.1016/0960-894X(95)00128-G

Molecular modeling studies on 11β-aminoethoxyphenyl and 7α-aminoethoxyphenyl estradiols. evidence suggesting a common hydrophobic pocket in estrogen receptor

Jacques H. Poupaert, Didier M. Lambert, Joseph Vamecq, Yusuf J. Abul-Hajj

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21 Scopus citations

Abstract

Molecular modeling studies were performed on 11β and 7α-aminoethoxyphenyl estradiols to determine whether these compounds may interact with the same receptor subsite. Energy minimization and molecular dynamics studies lend support to this hypothesis.

Original language	English (US)
Pages (from-to)	839-842
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/0960-894X(95)00128-G
State	Published - Apr 20 1995
Externally published	Yes

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Molecular modeling studies on 11β-aminoethoxyphenyl and 7α-aminoethoxyphenyl estradiols. evidence suggesting a common hydrophobic pocket in estrogen receptor. / Poupaert, Jacques H.; Lambert, Didier M.; Vamecq, Joseph et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 8, 20.04.1995, p. 839-842.

Research output: Contribution to journal › Article › peer-review

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AU - Abul-Hajj, Yusuf J.

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Molecular modeling studies on 11β-aminoethoxyphenyl and 7α-aminoethoxyphenyl estradiols. evidence suggesting a common hydrophobic pocket in estrogen receptor

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