Molecular pathways in malignant pleural mesothelioma

Bryan A. Whitson; Robert A Kratzke

doi:10.1016/j.canlet.2005.08.010

Molecular pathways in malignant pleural mesothelioma

Bryan A. Whitson, Robert A Kratzke

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Malignant pleural mesothelioma, although uncommon, is highly lethal. There is a high correlation between associated environmental exposure factors, carcinogens, and its development. Carcinogenesis is also mediated by genetic defects that result in loss of tumor suppressors or over expression of proto-oncogenes. Factors such as the loss of CDK inhibition function, IGF stimulatory pathways, p14^ARF, p15^INK4b, p16^INK4a, p21, and p53 loss or mutation, VEGF and COX over expression are discussed. Correlations to potential therapeutic modalities are made.

Original language	English (US)
Pages (from-to)	183-189
Number of pages	7
Journal	Cancer Letters
Volume	239
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.08.010
State	Published - Aug 8 2006

Bibliographical note

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Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

CDK inhibitor
IGF
Mesothelioma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AB - Malignant pleural mesothelioma, although uncommon, is highly lethal. There is a high correlation between associated environmental exposure factors, carcinogens, and its development. Carcinogenesis is also mediated by genetic defects that result in loss of tumor suppressors or over expression of proto-oncogenes. Factors such as the loss of CDK inhibition function, IGF stimulatory pathways, p14ARF, p15INK4b, p16INK4a, p21, and p53 loss or mutation, VEGF and COX over expression are discussed. Correlations to potential therapeutic modalities are made.

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Molecular pathways in malignant pleural mesothelioma

Abstract

Bibliographical note

Keywords

UN SDGs

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