Abstract
The activation of Ag-specific, Ia molecule-restricted TCR Vβ3+ T cell clones by staphylococcal toxic shock syndrome toxin-1 (TSST-1), was investigated. The results show that although Ag- and TSST-1-induced activation of T cell clones both require TCR expression and similar biologic activation signals, the Ia molecule requirement for TSST-1 recognition was much less stringent than that observed for antigenic peptide recognition. In addition, T cell clones recognized TSST-1 without processing by APC. These results suggest that the ability of TSST-1 to polyclonally activate T cells is dependent on TCR recognition of the intact toxin molecule bound to a nonpolymorphic region(s) of the Ia molecule resulting in the same activation events induced by Ag recognition.
Original language | English (US) |
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Pages (from-to) | 2089-2095 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 144 |
Issue number | 6 |
State | Published - Mar 15 1990 |