Molecular targets of phytochemicals for cancer prevention

Ki Won Lee; Ann M. Bode; Zigang Dong

doi:10.1038/nrc3017

Molecular targets of phytochemicals for cancer prevention

Ki Won Lee, Ann M. Bode, Zigang Dong

Hormel Institute

Research output: Contribution to journal › Review article › peer-review

383 Scopus citations

Abstract

Although successful for a limited number of tumour types, the efficacy of cancer therapies, especially for late-stage disease, remains poor overall. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals, which are thought to be safe for human use, have emerged as modulators of key cellular signalling pathways. The task now is to understand how these chemicals perturb these pathways by modelling their interactions with their target proteins.

Original language	English (US)
Pages (from-to)	211-218
Number of pages	8
Journal	Nature Reviews Cancer
Volume	11
Issue number	3
DOIs	https://doi.org/10.1038/nrc3017
State	Published - Mar 2011

Bibliographical note

Funding Information:
This article was supported by grants from the US National Institutes of Health CA077646, CA111536, CA111536, CA120388, ES016548 and R37CA081064, The Hormel Foundation, and the Leap Research Program (No. 2010-0029,233) and the World Class Institute Program founded by the Korea Research Foundation, Ministry of Education, Science and Technology, Republic of Korea.

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Molecular targets of phytochemicals for cancer prevention

Abstract

Bibliographical note

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