TY - JOUR
T1 - Monitoring plasma cardiac troponin I for the detection of myocardial injury after percutaneous transluminal coronary angioplasty
AU - Ricchiuti, Vincent
AU - Shear, Wendy S.
AU - Henry, Timothy D
AU - Paulsen, Pamela R.
AU - Miller, Elizabeth A.
AU - Apple, Fred S.
N1 - Funding Information:
This work was supported in part by a grant from Dade Behring Inc. We thank Claude Gronifer PhD for his statistical support.
PY - 2000
Y1 - 2000
N2 - The objective of this study was to detect myocardial injury defined by an increase of plasma cardiac troponin I (cTnI) following percutaneous transluminal coronary angioplasty (PTCA) and compare plasma cTnI with the risk of cardiac complications at 30 days. Plasma cTnI, creatine kinase (CK) MB, and total CK were determined in 83 patients before (baseline) and 6, 12 and 24 h after PTCA. Thirty-eight patients underwent conventional PTCA, 39 PTCA-stent and six rotational atherectomy. Patients with acute myocardial infarction (AMI) and increased pre-procedural cTnI >0.8 μg/l were categorized into group 1 (n = 23). The remaining 60 patients (pre-procedural cTnI = 0.8 μg/l) were categorized as follows: Group 2 (n = 15) AMI; group 3 (n = 20) unstable angina (UA); group 4 (n = 25) coronary artery disease (CAD). Twelve hours post-procedure, all three cardiac markers were more frequently increased over baseline in group 2 patients (40-60%) compared to patients in group 3 (5-29%, P < 0.03) or group 4 (0.5-5%, P < 0.01). This was also true for patients undergoing PTCA-stent compared to conventional PTCA or rotational atherectomy (27-40 vs. 4-14%, P < 0.02). cTnI was more sensitive (60%) to detect release of myocardial protein after PTCA compared to total CK (47%) or CKMB (43%). A moderate increase of cTnI (0.8-1.5 μg/l) in groups 2, 3 and 4 was associated with higher risk of complications 30 days post-procedure.
AB - The objective of this study was to detect myocardial injury defined by an increase of plasma cardiac troponin I (cTnI) following percutaneous transluminal coronary angioplasty (PTCA) and compare plasma cTnI with the risk of cardiac complications at 30 days. Plasma cTnI, creatine kinase (CK) MB, and total CK were determined in 83 patients before (baseline) and 6, 12 and 24 h after PTCA. Thirty-eight patients underwent conventional PTCA, 39 PTCA-stent and six rotational atherectomy. Patients with acute myocardial infarction (AMI) and increased pre-procedural cTnI >0.8 μg/l were categorized into group 1 (n = 23). The remaining 60 patients (pre-procedural cTnI = 0.8 μg/l) were categorized as follows: Group 2 (n = 15) AMI; group 3 (n = 20) unstable angina (UA); group 4 (n = 25) coronary artery disease (CAD). Twelve hours post-procedure, all three cardiac markers were more frequently increased over baseline in group 2 patients (40-60%) compared to patients in group 3 (5-29%, P < 0.03) or group 4 (0.5-5%, P < 0.01). This was also true for patients undergoing PTCA-stent compared to conventional PTCA or rotational atherectomy (27-40 vs. 4-14%, P < 0.02). cTnI was more sensitive (60%) to detect release of myocardial protein after PTCA compared to total CK (47%) or CKMB (43%). A moderate increase of cTnI (0.8-1.5 μg/l) in groups 2, 3 and 4 was associated with higher risk of complications 30 days post-procedure.
KW - Angioplasty
KW - Cardiac troponin
KW - Myocardial damage
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U2 - 10.1016/S0009-8981(00)00365-X
DO - 10.1016/S0009-8981(00)00365-X
M3 - Article
C2 - 11074073
AN - SCOPUS:0033767980
SN - 0009-8981
VL - 302
SP - 161
EP - 170
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1-2
ER -