Monocyte chemoattractant protein-1 and the blood-brain barrier

Yao Yao, Stella E. Tsirka

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation, is able to disrupt the integrity of BBB and modulate the progression of various diseases, including excitotoxic injury and hemorrhage. In this review, we first introduce the biochemistry and biology of MCP1, and then summarize the effects of MCP1 on BBB integrity as well as individual BBB components.

Original languageEnglish (US)
Pages (from-to)683-697
Number of pages15
JournalCellular and Molecular Life Sciences
Volume71
Issue number4
DOIs
StatePublished - Feb 2014

Keywords

  • Astrocytes
  • BBB
  • BM
  • BMECs
  • MCP1
  • Microglia
  • Neurons
  • Pericytes

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