Morphological and compositional monitoring of a new cell-free cartilage repair hydrogel technology - GelrinC by MR using semi-quantitative MOCART scoring and quantitative T2 index and new zonal T2 index calculation

S. Trattnig, K. Ohel, V. Mlynarik, V. Juras, S. Zbyn, A. Korner

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective: To evaluate cartilage repair tissue (RT) using MOCART scoring for morphological and T2 mapping for biochemical assessment following implantation of GelrinC, a biosynthetic, biodegradable hydrogel implant. Design: MR imaging (1.5/3T) was performed on 21 patients at six sites. Standard protocols were used for MOCART evaluation at 1 week (baseline) 1, 3, 6, 12, 18 and 24 months. Multi-echo SE was used for T2 mapping. Global (T2 in RT divided by T2 in normal cartilage) and zonal T2 index (deep T2 divided by superficial T2) of RT were calculated. Results: Average MOCART score was 71.8 (95% CI 62.2 to 81.3) at six, 75.2 (95% CI 62.8 to 87.5) at twelve, 71.8 (95% CI 55.4 to 88.2) at eighteen and 84.4 (95% CI 77.7 to 91.0) at twenty-four months. The global T2 index ranged between 0.8 and 1.2 (normal healthy cartilage) in 1/11 (9%) patients at baseline, 8/12 (67%) at 12 months, 11/13 (85%) at 18 months and 13/16 (81%) at 24 months. The zonal T2 index for RT was <20% difference to the zonal T2 index for normal cartilage in: 6/12 patients (50%) at 12 months, 7/13 (53.8%) at 18 months and 10/16 (63.5%) at 24 months. The standard deviation for T2 showed a significant decrease over the study. Conclusions: The increase of MOCART scores over follow-up indicates improving cartilage repair tissue. Global and zonal T2 repair values at 24 months reached normal cartilage in 81% and 63.5% of the patients respectively, reflecting collagen organization similar to hyaline cartilage.

Original languageEnglish (US)
Pages (from-to)2224-2232
Number of pages9
JournalOsteoarthritis and Cartilage
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
Funding for this study was provided by the Vienna Spots of Excellence of the Vienna Science and Technology Fund (WWTF): Vienna Advanced Imaging Center–VIACLIC FA102A0017 and FWF-DACH Programme 1652-B19 “Ultrahigh-field (7T) MR of early cartilage degeneration”. The financial support by the Austrian Federal Ministry of Science, Research and Economy and the National Foundation for Research, Technology and Development is gratefully acknowledged. The study sponsors did not have a role in study design, the collection and analysis of data, interpretation of results and decision to publish.

Publisher Copyright:
© 2015 The Authors. Elsevier Ltd and Osteoarthritis Research Society International.

Keywords

  • Articular cartilage
  • Cartilage repair tissue
  • GelrinC
  • Global and zonal T2 index
  • MR imaging
  • T2 mapping

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