Abstract
ALS is the most common adult-onset motor neuron disorder. ALS affects upper and lower motor neurons, resulting in a combination of spasticity, hyperreflexia, atrophy, and weakness. SMA is the most common childhood-onset motor neuron disorder and is an autosomal recessive disorder of the SMN gene. Other less common motor neuron disorders include SBMA, PLS, Hirayama disease, and viral poliomyelitis. The differential diagnosis and management of motor neuron disorders are discussed in this chapter.
Original language | English (US) |
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Title of host publication | Clinical Handbook of Neuromuscular Medicine |
Publisher | Springer International Publishing |
Pages | 57-74 |
Number of pages | 18 |
ISBN (Electronic) | 9783319671161 |
ISBN (Print) | 9783319671154 |
DOIs | |
State | Published - Jan 1 2018 |
Bibliographical note
Publisher Copyright:© Springer International Publishing AG, part of Springer Nature 2018.
Keywords
- Amyotrophic lateral sclerosis
- C9orf72
- Frontotemporal dementia
- Hirayama disease
- Poliomyelitis
- Primary lateral sclerosis
- Spinal muscular atrophy
- Spinobulbar muscular atrophy