Motor neuron disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

ALS is the most common adult-onset motor neuron disorder. ALS affects upper and lower motor neurons, resulting in a combination of spasticity, hyperreflexia, atrophy, and weakness. SMA is the most common childhood-onset motor neuron disorder and is an autosomal recessive disorder of the SMN gene. Other less common motor neuron disorders include SBMA, PLS, Hirayama disease, and viral poliomyelitis. The differential diagnosis and management of motor neuron disorders are discussed in this chapter.

Original languageEnglish (US)
Title of host publicationClinical Handbook of Neuromuscular Medicine
PublisherSpringer International Publishing
Pages57-74
Number of pages18
ISBN (Electronic)9783319671161
ISBN (Print)9783319671154
DOIs
StatePublished - Jan 1 2018

Keywords

  • Amyotrophic lateral sclerosis
  • C9orf72
  • Frontotemporal dementia
  • Hirayama disease
  • Poliomyelitis
  • Primary lateral sclerosis
  • Spinal muscular atrophy
  • Spinobulbar muscular atrophy

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