MRI study of white matter diffusion anisotropy in schizophrenia.

Babak A. Ardekani, Jay Nierenberg, Matthew J. Hoptman, Daniel C. Javitt, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

213 Scopus citations

Abstract

Diffusion tensor imaging (DTI) can provide information about brain white matter integrity. The results of DTI studies in schizophrenia are somewhat variable and could benefit from standardized image processing methods. Fourteen patients with schizophrenia or schizoaffective disorder and 14 healthy volunteers underwent DTI. Scans were analyzed using a rigorous voxelwise approach. The key dependent variable, fractional anisotropy, was lower for patients in the corpus callosum, left superior temporal gyrus, parahippocampal gyri, middle temporal gyri, inferior parietal gyri, medial occipital lobe, and the deep frontal perigenual region. Regions showing reduced white matter fractional anisotropy are known to be abnormal in schizophrenia. The voxelwise method used in the current study can provide the basis for hypothesis-driven research.

Original languageEnglish (US)
Pages (from-to)2025-2029
Number of pages5
JournalNeuroReport
Volume14
Issue number16
DOIs
StatePublished - Nov 14 2003

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