mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses

Basil S. Karam; Rachel S. Morris; Carolyn T. Bramante; Michael Puskarich; Emily J. Zolfaghari; Sahar Lotfi-Emran; Nicholas E. Ingraham; Anthony Charles; David J. Odde; Christopher J. Tignanelli

doi:10.1002/jmv.26728

mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses

Basil S. Karam, Rachel S. Morris, Carolyn T. Bramante, Michael Puskarich, Emily J. Zolfaghari, Sahar Lotfi-Emran, Nicholas E. Ingraham, Anthony Charles, David J. Odde, Christopher J. Tignanelli

Research output: Contribution to journal › Comment/debate › peer-review

54 Scopus citations

Abstract

In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.

Original language	English (US)
Pages (from-to)	1843-1846
Number of pages	4
Journal	Journal of Medical Virology
Volume	93
Issue number	4
DOIs	https://doi.org/10.1002/jmv.26728
State	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2020 Wiley Periodicals LLC

Keywords

COVID-19
mTOR
mTORi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses",

abstract = "In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.",

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AU - Bramante, Carolyn T.

AU - Puskarich, Michael

AU - Zolfaghari, Emily J.

AU - Lotfi-Emran, Sahar

AU - Ingraham, Nicholas E.

AU - Charles, Anthony

AU - Odde, David J.

AU - Tignanelli, Christopher J.

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mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses

Abstract

Bibliographical note

Keywords

UN SDGs

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