TY - JOUR
T1 - MTOR regulation of autophagy
AU - Jung, Chang Hwa
AU - Ro, Seung Hyun
AU - Cao, Jing
AU - Otto, Neil M
AU - Kim, Do-Hyung
PY - 2010
Y1 - 2010
N2 - Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.
AB - Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.
KW - Autophagy-related gene 1
KW - Autophagy-related gene 13
KW - Mammalian target of rapamycin
KW - UNC-51-like kinase 1
KW - UNC-51-like kinase 2
UR - http://www.scopus.com/inward/record.url?scp=77950501014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950501014&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2010.01.017
DO - 10.1016/j.febslet.2010.01.017
M3 - Review article
C2 - 20083114
AN - SCOPUS:77950501014
SN - 0014-5793
VL - 584
SP - 1287
EP - 1295
JO - FEBS Letters
JF - FEBS Letters
IS - 7
ER -