Multifocal motor neuropathy

Suraj Ashok Muley, Gareth J. Parry

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Multifocal motor neuropathy (MMN) was first described in 1988 as a purely motor neuropathy affecting multiple motor nerves. The diagnosis was based entirely on demonstrating electrophysiological evidence of a conduction block (CB) that selectively affected motor axons, with sparing of sensory axons even through the site of motor CB. Subsequently, a similar disorder was reported but with absence of demonstrable CB on routine nerve conduction studies and there is still some debate as to whether MMN without CB is related to MMN. MMN is thought to be an inflammatory neuropathy related to an immune attack on motor nerves. The conventional hypothesis is that the primary pathology is segmental demyelination, but recent research raises the possibility of a primary axonopathy. Anti-GM1 antibodies can be found in some patients but it is unclear whether these antibodies are pathogenic. Intravenous immunoglobulin is the mainstay of treatment but other immunosuppressive treatments can also be effective.

Original languageEnglish (US)
Pages (from-to)1201-1209
Number of pages9
JournalJournal of Clinical Neuroscience
Volume19
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Conduction block
  • Inflammatory neuropathy
  • Multifocal motor neuropathy

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