Multifunctional 3D Micro-Nanostructures Fabricated through Temporally Shaped Femtosecond Laser Processing for Preventing Thrombosis and Bacterial Infection

Yunlong Ma, Lan Jiang, Jie Hu, Hailin Liu, Suocheng Wang, Pei Zuo, Pengfei Ji, Liangti Qu, Tianhong Cui

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Blood-contacting medical devices that directly inhibit thrombosis and bacterial infection without using dangerous anticoagulant and antibacterial drugs can save countless lives but have proved extremely challenging. Here, a useful methodology is proposed that employs temporally shaped femtosecond laser ablation combined with fluorination to fabricate multifunctional three-dimensional (3D) micro-nanostructures with excellent hemocompatibility, zero cytotoxicity, outstanding biocompatibility, bacterial infection prevention, and long-term effectiveness on NiTi alloys. These multifunctional 3D micro-nanostructures present 0.1% hemolysis ratio and almost no platelet adhesion and activation, repel blood to inhibit blood coagulation in vitro, maintain 100% cell viability, and have exceptional stability over 6 months. Moreover, the multifunctional 3D micro-nanostructures simultaneously suppress bacterial colonization to form biofilm and kill 100% colonized Pseudomonas aeruginosa (P. aeruginosa) and 95.6% colonized Staphylococcus aureus (S. aureus) after 24 h of incubation, and bacterial residues can be easily removed. The fabrication method in this work has the advantages of simple processing, high efficiency, high quality, and high repeatability, and the new multifunctional 3D micro-nanostructures can effectively prevent thrombosis and bacterial infection, which can be widely applied to various clinical needs such as biomedical devices and implants.

Original languageEnglish (US)
Pages (from-to)17155-17166
Number of pages12
JournalACS Applied Materials and Interfaces
Volume12
Issue number15
DOIs
StatePublished - Apr 15 2020

Bibliographical note

Funding Information:
This work was supported by the National Key R&D Program of China (2018YFB1107200) and National Natural Science Foundation of China (NSFC) (51675048).

Keywords

  • bacterium-free
  • excellent hemocompatibility
  • multifunctional 3D micro-nanostructures
  • no contamination
  • temporally shaped femtosecond laser

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