Multifunctional analytical platform on a paper strip: Separation, preconcentration, and subattomolar detection

Abdennour Abbas, Andrew Brimer, Joseph M. Slocik, Limei Tian, Rajesh R. Naik, Srikanth Singamaneni

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10-18 M) detection limit using surface-enhanced Raman scattering as a transduction method. The microfluidic paper-based analytical device (μPAD) is made with a lithography-free process by a simple cut and drop method. Complex samples are separated by a surface chemical gradient created by differential polyelectrolyte coating of the paper. The μPAD with a starlike shape is designed to enable liquid handling by lateral flow without microchannel patterning. This design generates a rapid capillary-driven flow capable of dragging liquid samples as well as gold nanorods into a single cellulose microfiber, thereby providing an extremely preconcentrated and optically active detection spot.

Original languageEnglish (US)
Pages (from-to)3977-3983
Number of pages7
JournalAnalytical chemistry
Volume85
Issue number8
DOIs
StatePublished - Apr 16 2013

Fingerprint Dive into the research topics of 'Multifunctional analytical platform on a paper strip: Separation, preconcentration, and subattomolar detection'. Together they form a unique fingerprint.

Cite this