Multifunctional analytical platform on a paper strip: Separation, preconcentration, and subattomolar detection

Abdennour Abbas; Andrew Brimer; Joseph M. Slocik; Limei Tian; Rajesh R. Naik; Srikanth Singamaneni

doi:10.1021/ac303567g

Multifunctional analytical platform on a paper strip: Separation, preconcentration, and subattomolar detection

Abdennour Abbas, Andrew Brimer, Joseph M. Slocik, Limei Tian, Rajesh R. Naik, Srikanth Singamaneni

Bioproducts and Biosystems Engineering

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Abstract

We report a plasmonic paper-based analytical platform with functional versatility and subattomolar (<10^-18 M) detection limit using surface-enhanced Raman scattering as a transduction method. The microfluidic paper-based analytical device (μPAD) is made with a lithography-free process by a simple cut and drop method. Complex samples are separated by a surface chemical gradient created by differential polyelectrolyte coating of the paper. The μPAD with a starlike shape is designed to enable liquid handling by lateral flow without microchannel patterning. This design generates a rapid capillary-driven flow capable of dragging liquid samples as well as gold nanorods into a single cellulose microfiber, thereby providing an extremely preconcentrated and optically active detection spot.

Original language	English (US)
Pages (from-to)	3977-3983
Number of pages	7
Journal	Analytical Chemistry
Volume	85
Issue number	8
DOIs	https://doi.org/10.1021/ac303567g
State	Published - Apr 16 2013

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AU - Naik, Rajesh R.

AU - Singamaneni, Srikanth

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Multifunctional analytical platform on a paper strip: Separation, preconcentration, and subattomolar detection

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