TY - JOUR
T1 - Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury
AU - Başgöze, Zeynep
AU - Mirza, Salahudeen A.
AU - Silamongkol, Thanharat
AU - Hill, Dawson
AU - Falke, Conner
AU - Thai, Michelle
AU - Westlund Schreiner, Melinda
AU - Parenteau, Anna M.
AU - Roediger, Donovan J.
AU - Hendrickson, Timothy J.
AU - Mueller, Bryon A.
AU - Fiecas, Mark B.
AU - Klimes-Dougan, Bonnie
AU - Cullen, Kathryn R.
N1 - Funding Information:
This study was funded by the National Institutes of Mental Health R01MH107394.
Publisher Copyright:
Copyright © The Author(s), 2021. Published by Cambridge University Press.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala-mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala-mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI.
AB - Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala-mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala-mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI.
KW - RDoC
KW - adolescents
KW - nonsuicidal self-injury
KW - sustained threat
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U2 - 10.1017/S0954579421000754
DO - 10.1017/S0954579421000754
M3 - Article
C2 - 34486502
AN - SCOPUS:85115001744
SN - 0954-5794
VL - 33
SP - 1774
EP - 1792
JO - Development and psychopathology
JF - Development and psychopathology
IS - 5
ER -