Abstract
Chemical pH-oscillators provide a potential means for modulating the delivery of acidic or basic drugs across lipophilic membranes. Previous attempts to exploit this notion were not completely successful due to quenching of the pH oscillator in the presence of the drug, most likely by a buffering mechanism. Here we show that multiple, periodic pulses of drug flux across a membrane can be achieved when the concentration of drug is sufficiently low. Advantage is taken of a pH oscillator system whose periodicity is slower than that of previously considered oscillators.
Original language | English (US) |
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Pages (from-to) | 293-297 |
Number of pages | 5 |
Journal | Journal of Controlled Release |
Volume | 79 |
Issue number | 1-3 |
DOIs | |
State | Published - Feb 19 2002 |
Bibliographical note
Funding Information:This work was supported by NSF grant CHE-9996223.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
Keywords
- Chemical oscillator
- Membrane
- Modulated drug delivery
- Multipulse
- Permeability