TY - JOUR
T1 - Murine models of accelerated aging and musculoskeletal disease
AU - Hambright, William S.
AU - Niedernhofer, Laura J.
AU - Huard, Johnny
AU - Robbins, Paul D.
N1 - Publisher Copyright:
© 2019
PY - 2019/8
Y1 - 2019/8
N2 - The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the potential to slow or prevent multiple age-related musculoskeletal conditions simultaneously. However, the development of approaches to delay onset of age related diseases, including musculoskeletal pathologies, has been slowed by the relatively long lifespan of rodent models of aging. Thus, to expedite the development of therapeutic approaches for age-related musculoskeletal disease, the implementation of mouse models of accelerated musculoskeletal aging are of great utility. Currently there are multiple genetically diverse mouse models that mirror certain aspects of normal human and mouse aging. Here, we provide a review of some of the most relevant murine models of accelerated aging that mimic many aspects of natural musculoskeletal aging, highlighting their relative strengths and weaknesses. Importantly, these murine models of accelerated aging recapitulate phenotypes of musculoskeletal age-related decline observed in humans.
AB - The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the potential to slow or prevent multiple age-related musculoskeletal conditions simultaneously. However, the development of approaches to delay onset of age related diseases, including musculoskeletal pathologies, has been slowed by the relatively long lifespan of rodent models of aging. Thus, to expedite the development of therapeutic approaches for age-related musculoskeletal disease, the implementation of mouse models of accelerated musculoskeletal aging are of great utility. Currently there are multiple genetically diverse mouse models that mirror certain aspects of normal human and mouse aging. Here, we provide a review of some of the most relevant murine models of accelerated aging that mimic many aspects of natural musculoskeletal aging, highlighting their relative strengths and weaknesses. Importantly, these murine models of accelerated aging recapitulate phenotypes of musculoskeletal age-related decline observed in humans.
KW - Accelerated aging
KW - Mouse models
KW - Musculoskeletal diseases
KW - Progeria
KW - Senescence
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85065769544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065769544&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2019.03.002
DO - 10.1016/j.bone.2019.03.002
M3 - Article
C2 - 30844492
AN - SCOPUS:85065769544
SN - 8756-3282
VL - 125
SP - 122
EP - 127
JO - Bone
JF - Bone
ER -