Muscle immobilization and remobilization downregulates PGC-1α signaling and the mitochondrial biogenesis pathway

Medicine & Life Sciences

• Organelle Biogenesis 100%
• Immobilization 81%
• Down-Regulation 55%
• Muscles 47%
• Reactive Oxygen Species 17%
• Muscular Atrophy 16%
• GA-Binding Protein Transcription Factor 12%
• Nuclear Respiratory Factor 1 11%
• mitochondrial transcription factor A 11%
• Oxidative Stress 10%
• 8-epi-prostaglandin F2alpha 10%
• Hindlimb Suspension 9%
• Peroxisome Proliferator-Activated Receptors 8%
• Inflammation 8%
• Electron Transport Complex IV 8%
• Mitochondrial Proteins 8%
• Hindlimb 8%
• Cytochromes c 7%
• Mitochondrial DNA 7%
• Proteasome Endopeptidase Complex 7%
• Ubiquitin 7%
• Oxidation-Reduction 6%
• Proteolysis 6%
• Fingers 6%
• Leg 5%
• Skeletal Muscle 5%
• Interleukin-6 5%
• Body Weight 5%
• Tumor Necrosis Factor-alpha 5%
• Enzymes 3%
• Control Groups 3%
• Wounds and Injuries 3%
• Proteins 2%