Muscle synergies and complexity of neuromuscular control during gait in cerebral palsy

Katherine M. Steele, Adam Rozumalski, Michael H. Schwartz

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Aim: Individuals with cerebral palsy (CP) have impaired movement due to a brain injury near birth. Understanding how neuromuscular control is altered in CP can provide insight into pathological movement. We sought to determine if individuals with CP demonstrate reduced complexity of neuromuscular control during gait compared with unimpaired individuals and if changes in control are related to functional ability. Method: Muscle synergies during gait were retrospectively analyzed for 633 individuals (age range 3.9-70y): 549 with CP (hemiplegia, n=122; diplegia, n=266; triplegia, n=73; quadriplegia, n=88) and 84 unimpaired individuals. Synergies were calculated using non-negative matrix factorization from surface electromyography collected during previous clinical gait analyses. Synergy complexity during gait was compared with diagnosis subtype, functional ability, and clinical examination measures. Result: Fewer synergies were required to describe muscle activity during gait in individuals with CP compared with unimpaired individuals. Changes in synergies were related to functional impairment and clinical examination measures including selective motor control, strength, and spasticity. Interpretation: Individuals with CP use a simplified control strategy during gait compared with unimpaired individuals. These results were similar to synergies during walking among adult stroke survivors, suggesting similar neuromuscular control strategies between these clinical populations.

Original languageEnglish (US)
Pages (from-to)1176-1182
Number of pages7
JournalDevelopmental Medicine and Child Neurology
Volume57
Issue number12
DOIs
StatePublished - Dec 1 2015

Bibliographical note

Funding Information:
We thank the staff at the James R. Gage Center for Gait and Motion Analysis at Gillette Children’s Specialty Healthcare for data collection and feedback. This work was funded by National Institutes of Health grant K12HD073945. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.

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