Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

Shantu Amin; Nalband Hussain; George Balanikas; Keith Huie; Stephen S. Hecht

doi:10.1016/0304-3835(85)90059-X

Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

Shantu Amin, Nalband Hussain, George Balanikas, Keith Huie, Stephen S. Hecht

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

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Abstract

The mutagenic activities toward Salmonella typhimurium TA 100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF), 2-methylBkF, 8-methylBkF, 9-methylBkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxyBkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.

Original language	English (US)
Pages (from-to)	343-347
Number of pages	5
Journal	Cancer Letters
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(85)90059-X
State	Published - Apr 1985

Bibliographical note

Funding Information:
This study was supported by National Cancer Institute Grant CA 32242. We thank Mr. Jeffrey Rigotty for his excellent technical assistance.

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@article{f1b09d1888f346c885534d342bd349a0,

title = "Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes",

abstract = "The mutagenic activities toward Salmonella typhimurium TA 100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF), 2-methylBkF, 8-methylBkF, 9-methylBkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxyBkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.",

author = "Shantu Amin and Nalband Hussain and George Balanikas and Keith Huie and Hecht, {Stephen S.}",

note = "Funding Information: This study was supported by National Cancer Institute Grant CA 32242. We thank Mr. Jeffrey Rigotty for his excellent technical assistance.",

year = "1985",

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doi = "10.1016/0304-3835(85)90059-X",

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T1 - Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

AU - Amin, Shantu

AU - Hussain, Nalband

AU - Balanikas, George

AU - Huie, Keith

AU - Hecht, Stephen S.

N1 - Funding Information: This study was supported by National Cancer Institute Grant CA 32242. We thank Mr. Jeffrey Rigotty for his excellent technical assistance.

PY - 1985/4

Y1 - 1985/4

N2 - The mutagenic activities toward Salmonella typhimurium TA 100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF), 2-methylBkF, 8-methylBkF, 9-methylBkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxyBkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.

AB - The mutagenic activities toward Salmonella typhimurium TA 100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF), 2-methylBkF, 8-methylBkF, 9-methylBkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxyBkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.

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U2 - 10.1016/0304-3835(85)90059-X

DO - 10.1016/0304-3835(85)90059-X

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AN - SCOPUS:0021809125

SN - 0304-3835

VL - 26

SP - 343

EP - 347

JO - Cancer Letters

JF - Cancer Letters

IS - 3

ER -

Mutagenicity and tumor initiating activity of methylated benzo[k]fluoranthenes

Abstract

Bibliographical note

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