Myelin proteolipid protein induces demyelinating disease in mice

John L. Trotter, H. Brent Clark, Kelly G. Collins, Cindy L. Wegeschiede, Jo Anne D. Scarpellini

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85 Scopus citations


Using two methods of immunization (A and B), 5 10 (A) and 27 45 (B), BALB/c by J mice immunized with human myelin proteolipid protein developed a demyelinating disease with a spectrum of chronic progressive to relapsing-remitting courses. Demyelinative lesions were seen histopathologically in all clinically affected animals that were examined. Many of the clinically unaffected animals also had histopathologic evidence of demyelination. Some of the animals had evidence of multiple ages of foci of activity. Evidence is presented that contamination with myelin basic protein could not account for the disease. This is a new model for multiple sclerosis in mice.

Original languageEnglish (US)
Pages (from-to)173-188
Number of pages16
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - Jun 1987
Externally publishedYes


  • Allergic encephalomyelitis
  • Demyelinating disease
  • Myelin proteolipid protein


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