Myeloma-associated systemic amyloidosis presenting as chronic paronychia and palmodigital erythematous swelling and induration of the hands

Iftikhar Ahmed, Julie S. Cronk, Charles E. Crutchfield, Mark V. Dahl

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Mucocutaneous involvement occurs predominantly in primary systemic amyloidosis as well as in myeloma-associated systemic amyloidosis. It is rarely observed in other types of amyloidoses. Signs of such involvement may aid in the early diagnosis of the disease process. Herein, we describe a 64-year-old white male patient with myeloma-associated systemic amyloidosis in whom the disease presented with unique cutaneous lesions consisting of chronic paronychia and palmodigital erythematous swelling and induration of the hands. Following weekly regimens with prednisone (20 mg/day) and melphalan (2 mg/day) administered every 16 weeks, almost complete resolution of the cutaneous lesions was observed after 1 year of therapy. Also, in response to chemotherapy, modest regression of the myelomatous bone lesions and complete resolution of the underlying gammopathy occurred.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume42
Issue number2 II
DOIs
StatePublished - Feb 2000

Bibliographical note

Funding Information:
This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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