Myosin-driven intracellular transport

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18 Scopus citations

Abstract

The delivery of intracellular material within cells is crucial for maintaining normal function. Myosins transport a wide variety of cargo, ranging from vesicles to ribonuclear protein particles (RNPs), in plants, fungi, and metazoa. The properties of a given myosin transporter are adapted to move on different actin filament tracks, either on the disordered actin networks at the cell cortex or along highly organized actin bundles to distribute their cargo in a localized manner or move it across long distances in the cell. Transport is controlled by selective recruitment of the myosin to its cargo that also plays a role in activation of the motor.

Original languageEnglish (US)
Article numbera021972
JournalCold Spring Harbor Perspectives in Biology
Volume10
Issue number3
DOIs
StatePublished - Mar 2018

Bibliographical note

Funding Information:
I thank Ashley Arthur and Karl Petersen for helpful comments and extend apologies to my colleagues in the field for not citing all of the relevant papers owing to space limitations. The Titus lab is supported by a grant from the National Science Foundation (MCB-1244235).

Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

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