TY - JOUR
T1 - N-nitroso(2-hydroxyethyl)glycine, a urinary metabolite of n,n-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine
AU - Hecht, Stephen S.
AU - Morrison, J. Bradley
AU - Young, Ruth
PY - 1984/7
Y1 - 1984/7
N2 - Urinary metabolites in the rat of the carcinogen N,N-dinitrosopiperazine were identified as N-nitroso(2-hydroxyethyl)-glycine (22% of the dose), N-nitrosodiethanolamine (3%), 3-hydroxy-N-nitrosopyrrolidine (3%), and unchanged N, N-dinitrosopiperazine (18%). N-Nitroso(2-hydroxyethyl)glycine (1.6 μmol) was detected by gas chromatography-nitrosamine specific detection in the urine of rats treated by gavage with 19 umol of piperazine and 191 μmol of sodium nitrite. Since sensitive methods are available to quantify N-nitroso(2-hydroxyethyl)glycine in rat urine and human urine, it has potential utility as a monitor for in vivo formation of N,N-dinitrosopiperazine.
AB - Urinary metabolites in the rat of the carcinogen N,N-dinitrosopiperazine were identified as N-nitroso(2-hydroxyethyl)-glycine (22% of the dose), N-nitrosodiethanolamine (3%), 3-hydroxy-N-nitrosopyrrolidine (3%), and unchanged N, N-dinitrosopiperazine (18%). N-Nitroso(2-hydroxyethyl)glycine (1.6 μmol) was detected by gas chromatography-nitrosamine specific detection in the urine of rats treated by gavage with 19 umol of piperazine and 191 μmol of sodium nitrite. Since sensitive methods are available to quantify N-nitroso(2-hydroxyethyl)glycine in rat urine and human urine, it has potential utility as a monitor for in vivo formation of N,N-dinitrosopiperazine.
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U2 - 10.1093/carcin/5.7.979
DO - 10.1093/carcin/5.7.979
M3 - Article
C2 - 6733859
AN - SCOPUS:0021135983
SN - 0143-3334
VL - 5
SP - 979
EP - 981
JO - Carcinogenesis
JF - Carcinogenesis
IS - 7
ER -