N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes

Gunda I. Georg; Ping He; Joydeep Kant; Jeffrey Mudd

doi:10.1016/0040-4039(90)87005-K

N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes

Gunda I. Georg, Ping He, Joydeep Kant, Jeffrey Mudd

Medicinal Chemistry

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Abstract

The reaction of acid chlorides and N-vinyl imines results in the stereoselective formation of cis N-vinyl β-lactams. The N-vinyl protecting group can be removed either oxidatively or hydrolytically to yield N-unsubstituted β-lactams.

Original language	English (US)
Pages (from-to)	451-454
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/0040-4039(90)87005-K
State	Published - 1990

Bibliographical note

Funding Information:
Acknowledgements: These studies were supported by a grant from the American Heart Association Kansas Affiliate , The National Institutes of Health (GM 42260), and the General Research Fund of the University of Kansas.

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title = "N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes",

abstract = "The reaction of acid chlorides and N-vinyl imines results in the stereoselective formation of cis N-vinyl β-lactams. The N-vinyl protecting group can be removed either oxidatively or hydrolytically to yield N-unsubstituted β-lactams.",

author = "Georg, {Gunda I.} and Ping He and Joydeep Kant and Jeffrey Mudd",

note = "Funding Information: Acknowledgements: These studies were supported by a grant from the American Heart Association Kansas Affiliate , The National Institutes of Health (GM 42260), and the General Research Fund of the University of Kansas.",

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T1 - N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes

AU - Georg, Gunda I.

AU - He, Ping

AU - Kant, Joydeep

AU - Mudd, Jeffrey

N1 - Funding Information: Acknowledgements: These studies were supported by a grant from the American Heart Association Kansas Affiliate , The National Institutes of Health (GM 42260), and the General Research Fund of the University of Kansas.

PY - 1990

Y1 - 1990

N2 - The reaction of acid chlorides and N-vinyl imines results in the stereoselective formation of cis N-vinyl β-lactams. The N-vinyl protecting group can be removed either oxidatively or hydrolytically to yield N-unsubstituted β-lactams.

AB - The reaction of acid chlorides and N-vinyl imines results in the stereoselective formation of cis N-vinyl β-lactams. The N-vinyl protecting group can be removed either oxidatively or hydrolytically to yield N-unsubstituted β-lactams.

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N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes

Abstract

Bibliographical note

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