N-vinyl and N-unsubstituted β-lactams from 1-substituted 2-aza-1, 3-butadienes

Gunda I. Georg, Ping He, Joydeep Kant, Jeffrey Mudd

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The reaction of acid chlorides and N-vinyl imines results in the stereoselective formation of cis N-vinyl β-lactams. The N-vinyl protecting group can be removed either oxidatively or hydrolytically to yield N-unsubstituted β-lactams.

Original languageEnglish (US)
Pages (from-to)451-454
Number of pages4
JournalTetrahedron Letters
Issue number4
StatePublished - 1990

Bibliographical note

Funding Information:
Acknowledgements: These studies were supported by a grant from the American Heart Association Kansas Affiliate , The National Institutes of Health (GM 42260), and the General Research Fund of the University of Kansas.


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