Naive T cell homeostasis: From awareness of space to a sense of place

Kensuke Takada, Stephen C Jameson

Research output: Contribution to journalReview articlepeer-review

240 Scopus citations


The peripheral naive T cell pool is fairly stable in number, diversity and functional competence in the absence of vigorous immune responses. However, this apparent tranquillity is not an intrinsic property of T cells but involves continuous tuning of the T cell pool composition by homeostatic signals. In the past decade, studies have revealed that naive T cells rely on combinatorial signals from self-peptide-MHC complexes and interleukin-7 for their physical and functional maintenance. Competition for these factors dictates T cell 'space'. In addition, recent studies show that these and other homeostatic factors are offered to T cells on stromal cell networks, which also serve to guide T cell trafficking in secondary lymphoid organs. Such findings suggest the importance of 'place' in the perception and integration of homeostatic cues for the maintenance and functional tuning of the naive T cell pool.

Original languageEnglish (US)
Pages (from-to)823-832
Number of pages10
JournalNature Reviews Immunology
Issue number12
StatePublished - Dec 1 2009

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