Naloxone's anorectic effect is dependant upon the relative palatability of food

S. Q. Giraudo, M. K. Grace, Catherine Welch, Charles J Billington, Allen S Levine

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


It has been suggested that opioids modify food intake by enhancing palatability. In the present series of studies we evaluated the effect of naloxone on food intake of a preferred food (chocolate chip cookies), normal rat chow, and an "aversive" food (high fiber chow). We found that naloxone decreased 18- and 48-h deprivation-induced intake of chocolate chip cookies much more potently than that of chow, when these foods were presented on separate occasions. When these foods were presented concurrently, this difference in naloxone's potency was no longer apparent. When rats were offered high fiber chow, only the 10 mg/kg dose of naloxone decreased intake. In these same rats naloxone significantly decreased normal chow intake at a dose of 0.1 mg/kg. Thus, naloxone's ability to decrease food intake appears to be dependent upon the palatability of the food.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - Dec 1993

Bibliographical note

Funding Information:
This work was supported by the Department of Veterans Affairs, the National Institute of Drug Abuse DA03999, and the National Institutes of Health DK42698.


  • Feeding
  • Naloxone
  • Opiates
  • Opioid
  • Palatability
  • Reward


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