Nanofibers and lyotropic liquid crystals from a class of self-assembling β-peptides

William C. Pomerantz, Virany M. Yuwono, Claire L. Pizzey, Jeffery D. Hartgerink, Nicholas L. Abbott, Samuel H. Gellman

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

(Figure Presented) More than a pretty phase: A class of helical b-peptides has been discovered that form lyotropicliquid-c rystalline (LC) phases in water. The β-peptide sequence strongly affects the mode of assembly and ultimately whether a LC phase is formed. For a non-globally amphiphilic β-peptide that can form a LC phase, cryo-TEM revealed thin fibers several micrometers in length, consistent with Onsager theory.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number7
DOIs
StatePublished - Feb 1 2008

Keywords

  • Liquid crystals
  • Lyotropic phases
  • Nanofibers
  • Peptides
  • Self-assembly

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