TY - GEN
T1 - Nanoparticle Enhanced Thermal Therapies
AU - Shenoi, Mithun M.
AU - Anderson, J. Kyle
AU - Bischof, John C.
PY - 2009
Y1 - 2009
N2 - Thermal therapies such as hyperthermia, radiofrequency ablation, cryoablation, etc. have shown great potential and are gaining increasing clinical acceptance in the treatment of solid tumors. However, these treatment modalities are limited by the size of tumor that can be treated, incomplete tumor kill, and damage to adjacent normal tissues. To address these limitations, the concept of adjuvant-assisted thermal therapies has been proposed and tested to enhance the tumor destructive effects of thermal therapies. CYT-6091, a pegylated colloidal gold nanoparticle containing TNF-alpha bound to its surface, has been extensively investigated in our lab as an adjuvant to enhance thermal therapies. This paper describes our investigations of nanoparticle enhanced thermal therapies in various preclinical and translational models of solid tumors.
AB - Thermal therapies such as hyperthermia, radiofrequency ablation, cryoablation, etc. have shown great potential and are gaining increasing clinical acceptance in the treatment of solid tumors. However, these treatment modalities are limited by the size of tumor that can be treated, incomplete tumor kill, and damage to adjacent normal tissues. To address these limitations, the concept of adjuvant-assisted thermal therapies has been proposed and tested to enhance the tumor destructive effects of thermal therapies. CYT-6091, a pegylated colloidal gold nanoparticle containing TNF-alpha bound to its surface, has been extensively investigated in our lab as an adjuvant to enhance thermal therapies. This paper describes our investigations of nanoparticle enhanced thermal therapies in various preclinical and translational models of solid tumors.
UR - http://www.scopus.com/inward/record.url?scp=77950989871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950989871&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5333447
DO - 10.1109/IEMBS.2009.5333447
M3 - Conference contribution
C2 - 19964027
AN - SCOPUS:77950989871
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 1979
EP - 1982
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -