TY - GEN
T1 - Nanoparticle heating
T2 - Energy-Based Treatment of Tissue and Assessment VI
AU - Qin, Zhenpeng
AU - Etheridge, Michael
AU - Bischof, John C.
PY - 2011
Y1 - 2011
N2 - Biomedical applications of nanoparticle heating range in scale from molecular activation (i.e. molecular beacons, protein denaturation, lipid melting and drug release), cellular heating (i.e. nanophotolysis and membrane permeability control and rupture) to whole tumor heating (deep and superficial). This work will present a review on the heating of two classes of biologically compatible metallic nanoparticles: iron oxide and gold with particular focus on spatial and temporal scales of the heating event. The size range of nanoparticles under discussion will focus predominantly in the 10 - 200 nm diameter size range. Mechanisms of heating range from Néelian and Brownian relaxation due to magnetic susceptibility at 100s of kHz, optical absorption due to VIS and NIR lasers and "Joule" heating at higher frequency RF (13.56 MHz). The heat generation of individual nanoparticles and the thermal responses at nano-, micro-, and macroscales are presented. This review will also discuss how to estimate a specific absorption rate (SAR, W/g) based on individual nanoparticles heating in bulk samples. Experimental setups are designed to measure the SAR and the results are compared with theoretical predictions.
AB - Biomedical applications of nanoparticle heating range in scale from molecular activation (i.e. molecular beacons, protein denaturation, lipid melting and drug release), cellular heating (i.e. nanophotolysis and membrane permeability control and rupture) to whole tumor heating (deep and superficial). This work will present a review on the heating of two classes of biologically compatible metallic nanoparticles: iron oxide and gold with particular focus on spatial and temporal scales of the heating event. The size range of nanoparticles under discussion will focus predominantly in the 10 - 200 nm diameter size range. Mechanisms of heating range from Néelian and Brownian relaxation due to magnetic susceptibility at 100s of kHz, optical absorption due to VIS and NIR lasers and "Joule" heating at higher frequency RF (13.56 MHz). The heat generation of individual nanoparticles and the thermal responses at nano-, micro-, and macroscales are presented. This review will also discuss how to estimate a specific absorption rate (SAR, W/g) based on individual nanoparticles heating in bulk samples. Experimental setups are designed to measure the SAR and the results are compared with theoretical predictions.
KW - Gold nanoparticle
KW - Iron oxide nanoparticle
KW - Joule heating
KW - Magnetic fluid hyperthermia
KW - Nanoparticle heating
KW - Neel and brownian relaxation
KW - Photothermal therapy
KW - Plasmon resonance
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U2 - 10.1117/12.876528
DO - 10.1117/12.876528
M3 - Conference contribution
AN - SCOPUS:79953815543
SN - 9780819484383
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Energy-Based Treatment of Tissue and Assessment VI
Y2 - 23 January 2011 through 24 January 2011
ER -