Uranium silicide compounds exhibit a range of attractive material properties for nuclear fuel applications, but little is known regarding their mechanical behavior. Nanoindentation has seen limited use for evaluation of the mechanical properties of nuclear fuel materials. The mechanical properties of nuclear fuels, and ceramics in particular, can be challenging to assess through conventional mechanical testing methods. The structure of nuclear fuels at high burnup can prove to be especially difficult given the significant changes in both chemistry and microstructure caused by fission products. Nanoindentation may therefore prove to be a valuable addition to post irradiation examination. The present focus is assessment of the room temperature modulus and hardness of U3Si2, U3Si5 and USi materials.