Natriuretic Peptides, Their Receptors and Therapeutic Applications

K. Barbieri, L. R. Potter

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Natriuretic peptides are an ancient family of hormones/paracrine factors that regulate blood pressure, cardiovascular homeostasis, and long bone growth. The mammalian family consists of atrial natriuretic peptide, B-type natriuretic peptide, and C-type natriuretic peptide. All three peptides are derived from separate genes, but share a common 17-amino-acid disulfide ring that is required for biological activity. A family of three cell-surface receptors binds natriuretic peptides. Two are receptor guanylyl cyclases, enzymes that catalyze the synthesis of the intracellular second messenger, cyclic guanosine mononucleotide, whereas one is a clearance receptor that controls local natriuretic peptide concentrations via constitutive receptor-mediated endocytosis. In this article, the structure, function, and regulation of each hormone and receptor are discussed.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages225-228
Number of pages4
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • ANF
  • CGMP
  • Guanylyl cyclase
  • Heart failure
  • Skeletal dysplasia

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